NOX4 Polyclonal Antibody

Background:
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
Kidney oxidase 1, Kidney oxidase-1, Kidney superoxide producing NADPH oxidase, Kidney superoxide-producing NADPH oxidase, KOX 1, KOX, Kox-1, KOX1, NADPH, NADPH oxidase 4, Nox4, NOX4, Renal NAD(P)H oxidase, Renal NAD(P)H-oxidase, RENOX

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse NOX4

Swissprot: Q9NPH5,Q9JHI8,Q924V1

Calculated MW: 70 kDa
Observed MW: 70 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:1000-1:2000, IHC 1:400-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.