NOXA Antibody (BH3 Domain Specific) Blocking peptide
€363.00
In stock
SKU
AC-BP1316a
Background:
The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis.
Other Names:
Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1316a was selected from the region of human Noxa BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PMAIP1
Gene ID: 5366
Primary Accession: Q13794
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis.
Other Names:
Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1316a was selected from the region of human Noxa BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PMAIP1
Gene ID: 5366
Primary Accession: Q13794
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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