Noxa polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10502-100
Catalog Number: AC-ABV10502-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data s µggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These s µggest Noxa may represent a candidate mediator of p53-induced apoptosis.
Other Names:
PMAIP1 , NOXA , APR
Primary Accession: Q13794
Other Accession: AAH32663
Gene Name: PMAIP1
Gene ID: 5366
Concentration (mg/ml): 0.2 mg/ml
Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data s µggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These s µggest Noxa may represent a candidate mediator of p53-induced apoptosis.
Other Names:
PMAIP1 , NOXA , APR
Primary Accession: Q13794
Other Accession: AAH32663
Gene Name: PMAIP1
Gene ID: 5366
Concentration (mg/ml): 0.2 mg/ml
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