NOXA1 polyclonal, anti-human

Quantity: 100 µg

Background:
NOXA1(NADPH oxidase activator 1), also called NOX ACTIVATOR 1 or p51-NOX, is an enzyme that in humans is encoded by the NOXA1 gene. Hartz(2007) mapped the NOXA1 gene to chromosome 9q34.3 based on an alignment of the NOXA1 sequence with the genomic sequence(build 36.1). Banfi et al.(2003) mapped the mouse Noxa1 gene to chromosome 2. Using yeast 2-hybrid assays, Takeya et al.(2003) showed that human p51-NOX interacted with constitutively active forms of RAC1 and RAC2. In vitro binding assays revealed that p51-NOX bound GTP-bound RAC1, but not GDP-bound RAC1. p51-NOX also bound p47-PHOX(NCF1) and p41-NOX(NOXO1), and trp436 within the SH3 domain of p51-NOX was required for these interactions. Human cell lines or COS-7 cells cotransfected with p51-NOX and p41-NOX and either gp91-PHOX(CYBB) or NOX1 produced superoxide. Cells individually transfected with NOX1, p41-NOX, or p51-NOX and cells transfected with only p41-NOX and p51-NOX showed no superoxide production.

Description:
Rabbit IgG polyclonal antibody for NADPH oxidase activator 1 (NOXA1) detection. Tested with WB in Human.

Synonyms:
Antigen NY CO 31 antibody, Antigen NY-CO-31 antibody, FLJ25475 antibody, Inhibitory NADPH oxidase activator 1 antibody, MGC131800 antibody, NADPH oxidase activator 1 antibody, NCF2 like protein antibody, NCF2-like protein antibody, NOX activator 1 antibody, NOXA 1 antibody, Noxa1 antibody, NOXA1_HUMAN antibody, NY CO 31 antibody, p51 nox antibody, p51-nox antibody, p51NOX antibody, P67phox like factor antibody, P67phox-like factor antibody, SDCCAG31 antibody, Serologically defined colon cancer antigen 31 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human NOXA1(176-195aa RQVPRGEVFRPHRWHLKHLE).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.