NPC1 polyclonal (Center), anti-human
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In stock
SKU
AC-AP13472c
Catalog Number: AC-AP13472c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33297
Applications: WB, IF, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33297
Applications: WB, IF, IHC-P
Datasheet
Request Information
Background:
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Other Names:
Niemann-Pick C1 protein, NPC1
Target/Specificity:
This NPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-620 amino acids from the Central region of human NPC1.
Antigen Region:
591-620
Antigen Type: Synthetic Peptide
Gene Name: NPC1 (HGNC:7897)
Gene ID: 4864
Primary Accession: O15118
NCBI Accession: NP_000262.2
Other Accession: NP_000262.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Other Names:
Niemann-Pick C1 protein, NPC1
Target/Specificity:
This NPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-620 amino acids from the Central region of human NPC1.
Antigen Region:
591-620
Antigen Type: Synthetic Peptide
Gene Name: NPC1 (HGNC:7897)
Gene ID: 4864
Primary Accession: O15118
NCBI Accession: NP_000262.2
Other Accession: NP_000262.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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