NPHS2 Polyclonal Antibody

Background:
This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN). SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined.

Research Area: Cancer, Cell biology, Signal transduction, Tags and Cell markers

Synonyms:
Nephrosis 2, idiopathic, steroid resistant (podocin), nephrosis 2, idiopathic, steroid resistant, NPHS2, NPHS2 gene, PDCN, PODO, Podocin, SRN1

Immunogen: Synthetic peptide of human NPHS2

Swissprot: Q9NP85
Gene Accession: NP_055440

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-22296/sc-22294/sc-21009