NPM (phospho-T199) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4655
Background:
Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Alternative Name:
Nucleophosmin, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-NPM (T199) polyclonal antibody detects endogenous levels of NPM protein only when phosphorylated at Thr199.
Immunogen:
Synthetic phosphopeptide derived from human NPM around the phosphorylation site of Threonine 199.
MW: ~ 38 kDa
Swis Prot.: P06748
Purification & Purity:
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Alternative Name:
Nucleophosmin, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-NPM (T199) polyclonal antibody detects endogenous levels of NPM protein only when phosphorylated at Thr199.
Immunogen:
Synthetic phosphopeptide derived from human NPM around the phosphorylation site of Threonine 199.
MW: ~ 38 kDa
Swis Prot.: P06748
Purification & Purity:
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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