NPM1 (clone AT23F1), anti-human

Description
NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded and double-strandednucleic acids, but it binds preferentially G-Quadruplex forming nucleic acids. It is involved in the biogenesisof ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation throughSUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions.It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation ortreatment with anticancer drugs. The protein is phosphorylated. Chromosomal aberrations involving NPM1 werefound in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acutemyelogenous leukemia. It has been found in the cytoplasm in patients with primary acute myelogenous leukemia.Alternative Names
Nucleophosmin, B23, NPMConcentration
1mg/ml (determined by BCA assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.