NPM1 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM2201b
Catalog Number: AC-AM2201b
Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 1042CT5.2.1
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 1042CT5.2.1
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
Other Names:
Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM
Target/Specificity:
Purified His-tagged NPM1 protein was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: NPM1
Gene ID: 4869
Primary Accession: P06748
NCBI Accession: NP_001032827.1;NP_002511.1;NP_954654.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
Other Names:
Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM
Target/Specificity:
Purified His-tagged NPM1 protein was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: NPM1
Gene ID: 4869
Primary Accession: P06748
NCBI Accession: NP_001032827.1;NP_002511.1;NP_954654.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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