NPM1 Polyclonal Antibody

Background:
Nucleophosmin (NPM1, B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
B23, MGC104254, NO38, NPM, NPM, NPM1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Nucleophosmin (nucleolar phosphoprotein B23 numatrin), Nucleophosmin, nucleophosmin nucleoplasmin family member 1, Nucleophosmin/nucleoplasmin family member 1, Numatrin

Immunogen: Recombinant Mouse Nucleophosmin protein

Swissprot: Q61937
Gene ID: 18148

Calculated MW: 32 kDa
Observed MW: 37 kDa

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Concentration: 1mg/mL
Dilution:
WB 1:10000-1:20000
IHC 1:200-1:500

Storage:
Store at -20℃. Avoid freeze / thaw cycles.