NPRL3 polyclonal, anti-human, mouse

Background:
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Synonyms: C16orf35, CGTHBA, MARE

Cellular Location: Cytoplasm 

Immunogen:
Recombinant protein of human NPRL3

Gene Symbol: NPRL3

Gene ID: 8131

Swiss prot: Q12980

Calculated MW: 64kDa

Recommended dilution:
WB 1:5000-8000, IHC 1:100-300,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20°C. Avoid freeze / thaw cycles.