NQO1 polyclonal, anti-human

Quantity: 100 µl

Description:
NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxyfying enzyme and is involved in the body's protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimer's disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.

Synonyms:
NAD(P)H Dehydrogenase (Quinine) 1 (NQO1), Quinone Reductase 1 (QR1), DT-Diaphorase (DTD), Azoreductase, Phylloquinone Reductase, Menadione Reductase, Dioxin-inducible 1, Disphorase-4 (DIA4), NAD(P)H:Quinone Oxireductase, NAD(P)H:Quinone Oxidoreductase 1

Isotype: Rabbit Polyclonal

Immunogen:
Recombinant human NQO1.

Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Specificity:
Recognizes human NQO1. Detects a band of ~30kDa by Western blot.

Reactivity: human

Applications: ELISA, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)