NQO1 Polyclonal Antibody

Background:
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
DHQU, DIA4, DTD, NMOR1, NMORI, QR1, NQO1

Immunogen: A synthetic peptide of human NQO1 (NP_000894.1).

Swissprot: P15559
Gene ID: 1728

Calculated MW: 26 kDa/27 kDa/30 kDa
Observed MW: 32 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.