NR0B2 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP11075c
Background:
The protein encoded by this gene is an unusual orphanreceptor that contains a putative ligand-binding domain but lacks aconventional DNA-binding domain. The gene product is a member ofthe nuclear hormone receptor family, a group of transcriptionfactors regulated by small hydrophobic hormones, a subset of whichdo not have known ligands and are referred to as orphan nuclearreceptors. The protein has been shown to interact with retinoid andthyroid hormone receptors, inhibiting their ligand-dependenttranscriptional activation. In addition, interaction with estrogenreceptors has been demonstrated, leading to inhibition of function.Studies suggest that the protein represses nuclear hormonereceptor-mediated transactivation via two separate steps:competition with coactivators and the direct effects of itstranscriptional repressor function.
Other Names:
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP
Gene Name: NR0B2
Gene ID: 8431
Primary Accession: Q15466
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is an unusual orphanreceptor that contains a putative ligand-binding domain but lacks aconventional DNA-binding domain. The gene product is a member ofthe nuclear hormone receptor family, a group of transcriptionfactors regulated by small hydrophobic hormones, a subset of whichdo not have known ligands and are referred to as orphan nuclearreceptors. The protein has been shown to interact with retinoid andthyroid hormone receptors, inhibiting their ligand-dependenttranscriptional activation. In addition, interaction with estrogenreceptors has been demonstrated, leading to inhibition of function.Studies suggest that the protein represses nuclear hormonereceptor-mediated transactivation via two separate steps:competition with coactivators and the direct effects of itstranscriptional repressor function.
Other Names:
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP
Gene Name: NR0B2
Gene ID: 8431
Primary Accession: Q15466
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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