NR0B2 antibody (clone 1A11), anti-human
€435.00
In stock
SKU
AC-AT3092a
Catalog Number: AC-AT3092a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT3092a">Request Information
Background:
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Other Names:
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP
Antigen Type:
Recombinant Protein
Gene Name: NR0B2
Gene ID: 8431
NCBI Accession: NP_068804.1
Primary Accession: Q15466
Other Accession: BC030207
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Other Names:
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP
Antigen Type:
Recombinant Protein
Gene Name: NR0B2
Gene ID: 8431
NCBI Accession: NP_068804.1
Primary Accession: Q15466
Other Accession: BC030207
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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