NR0B2 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7299
Background:
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Alternative Name:
NR0B2, NR0B2_HUMAN, Nr0b2a, Nuclear receptor subfamily 0 group B member 2, Nuclear receptor subfamily 0, group B, member 2a, Orphan nuclear receptor SHP, SHP, SHP-1, Shp1, Small heterodimer partner,
Application Dilution: WB: 1:500~1:2000
Specificity: NR0B2 polyclonal antibody detects endogenous levels of NR0B2 protein.
Immunogen:
Recombinant full length Human NR0B2.
MW: ~28 kDa
Swis Prot.: Q15466
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Alternative Name:
NR0B2, NR0B2_HUMAN, Nr0b2a, Nuclear receptor subfamily 0 group B member 2, Nuclear receptor subfamily 0, group B, member 2a, Orphan nuclear receptor SHP, SHP, SHP-1, Shp1, Small heterodimer partner,
Application Dilution: WB: 1:500~1:2000
Specificity: NR0B2 polyclonal antibody detects endogenous levels of NR0B2 protein.
Immunogen:
Recombinant full length Human NR0B2.
MW: ~28 kDa
Swis Prot.: Q15466
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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