NR0B2 Polyclonal Antibody

Background:
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction

Synonyms:
NR0B2, NR0B2, Nr0b2a, Nuclear receptor subfamily 0 group B member 2, Nuclear receptor subfamily 0, group B, member 2a, Orphan nuclear receptor SHP, SHP, SHP-1, Shp1, Small heterodimer partner

Immunogen: Fusion protein of human NR0B2

Swissprot: Q15466
Gene Accession: BC030207

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:1000-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.