NR1H3 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cardiovascular,Signal Transduction,Epigenetics and Nuclear Signaling,Signal Transduction,Cancer,Metabolism

Synonyms:
Liver X receptor alpha, LXR a, LXRA, NR1H3, NR1H3_HUMAN, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR alpha, Oxysterols receptor LXR-alpha, RLD 1, RLD1

Immunogen: Recombinant Rat Oxysterols receptor LXR-alpha protien

Swissprot: Q62685

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: IHC 1:100-1:400

Storage:
Store at -20°C. Avoid freeze / thaw cycles.