NR1H4 polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP19002a
Catalog Number: AC-AP19002a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39466
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39466
Applications: WB
Datasheet
Request Information
Background:
NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Other Names:
Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14
Target/Specificity:
This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4.
Antigen Region:
18-46
Antigen Type: Synthetic Peptide
Gene Name: NR1H4
Gene ID: 9971
Primary Accession: Q96RI1
NCBI Accession: NP_001193906.1;NP_001193907.1;NP_001193908.1;NP_001193921.1;NP_001193922.1;NP_005114.1
Other Accession: Q3SZL0; NP_005114.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Other Names:
Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14
Target/Specificity:
This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4.
Antigen Region:
18-46
Antigen Type: Synthetic Peptide
Gene Name: NR1H4
Gene ID: 9971
Primary Accession: Q96RI1
NCBI Accession: NP_001193906.1;NP_001193907.1;NP_001193908.1;NP_001193921.1;NP_001193922.1;NP_005114.1
Other Accession: Q3SZL0; NP_005114.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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