NR1I3 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP14587c
Background:
This gene encodes a member of the nuclear receptorsuperfamily, and is a key regulator of xenobiotic and endobioticmetabolism. The protein binds to DNA as a monomer or a heterodimerwith the retinoid X receptor and regulates the transcription oftarget genes involved in drug metabolism and bilirubin clearance,such as cytochrome P450 family members. Unlike most nuclearreceptors, this transcriptional regulator is constitutively activein the absence of ligand but is regulated by both agonists andinverse agonists. Ligand binding results in translocation of thisprotein to the nucleus, where it activates or represses target genetranscription. These ligands include bilirubin, a variety offoreign compounds, steroid hormones, and prescription drugs.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Other Names:
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Gene Name: NR1I3
Gene ID: 9970
Primary Accession: Q14994
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the nuclear receptorsuperfamily, and is a key regulator of xenobiotic and endobioticmetabolism. The protein binds to DNA as a monomer or a heterodimerwith the retinoid X receptor and regulates the transcription oftarget genes involved in drug metabolism and bilirubin clearance,such as cytochrome P450 family members. Unlike most nuclearreceptors, this transcriptional regulator is constitutively activein the absence of ligand but is regulated by both agonists andinverse agonists. Ligand binding results in translocation of thisprotein to the nucleus, where it activates or represses target genetranscription. These ligands include bilirubin, a variety offoreign compounds, steroid hormones, and prescription drugs.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Other Names:
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Gene Name: NR1I3
Gene ID: 9970
Primary Accession: Q14994
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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