NR1I3 polyclonal, anti-human, mouse

Background:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: CAR, CAR1, MB67

Cellular Location: Cytoplasm Nucleus cytoskeleton

Immunogen:
Recombinant protein of human NR1I3

Gene Symbol: NR1I3

Gene ID: 9970

Swiss prot: Q14994

Calculated MW: 40kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.