NR1I3 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP14587c
Catalog Number: AC-AP14587c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34573
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34573
Applications: WB
Datasheet
Request Information
Background:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Target/Specificity:
This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.
Antigen Region:
155-183
Antigen Type: Synthetic Peptide
Gene Name: NR1I3
Gene ID: 9970
Primary Accession: Q14994
NCBI Accession: NP_001070938.1;NP_001070939.1;NP_001070940.1;NP_001070941.1;NP_001070944.1;NP_001070945.1;NP_001070947.1;NP_001070948.1;NP_001070949.1;NP_001070950.1;NP_005113.1
Other Accession: NP_005113.1;NP_001070948.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Target/Specificity:
This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.
Antigen Region:
155-183
Antigen Type: Synthetic Peptide
Gene Name: NR1I3
Gene ID: 9970
Primary Accession: Q14994
NCBI Accession: NP_001070938.1;NP_001070939.1;NP_001070940.1;NP_001070941.1;NP_001070944.1;NP_001070945.1;NP_001070947.1;NP_001070948.1;NP_001070949.1;NP_001070950.1;NP_005113.1
Other Accession: NP_005113.1;NP_001070948.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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