NR2C2 (clone 8F2E8), anti-

Background:
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Research Area: Epigenetics and nuclear signaling

Synonyms: TR4, TAK1

Immunogen: Purified recombinant fragment of human NR2C2 (AA: 62-356) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage