NR3C1 (phospho-S203) pAb, anti-human, mouse, rat

Background:
The glucocorticoid receptor (GR) is an ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis and cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the nonligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Alternative Name:
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL

Application Dilution:
WB: 1:500~1:1000

Specificity: NR3C1 (Phospho-S203) polyclonal antibody detects endogenous levels of NR3C1 protein only when phosphorylated at Ser203 .

Immunogen:
Synthetic phosphopeptide derived from human NR3C1 around the phosphorylation site of Serine203.

MW: ~ 95 kDa

Swiss-Prot: P04150

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.