NR3C1 polyclonal, anti-human

Background:
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696).Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Synonyms: GCCR, GCR, GCRST, GR, GRL, glucocorticoid receptor

Cellular Location: Nucleus Cytoplasm  

Immunogen:
Recombinant protein of human NR3C1

Gene Symbol: NR3C1

Gene ID: 2908

Swiss prot: P04150

Calculated MW: 52/76/61/65/82/86kDa

Recommended dilution:
WB 1:5000-8000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20°C. Avoid freeze / thaw cycles.