NR3C2 polyclonal, anti-human, mouse

Background:
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Synonyms: MCR, MLR, MR, NR3C2VIT

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human NR3C2

Gene Symbol: NR3C2

Gene ID: 4306

Swiss prot: P08235

Calculated MW: 107kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.