NRAS Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7745b
Background:
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7745b was selected from the C-term region of human NRAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7745b was selected from the C-term region of human NRAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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