NRas polyclonal, anti-human, mouse, rat

Protein Family: GTP-binding Proteins

Pathway and Disease: Signal Transduction, Cell Motility, Cell Communication, Immune System, Endocrine System, Nervous and Sensory Systems, Development and Behavior, Cancers

Description:
GTPase NRas (NRas) binds GDP/GTP and possess intrinsic GTPase activity. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML). JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.

Alternate Names: GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P01111

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NRas.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.