NRAS polyclonal, anti-human, mouse, rat, pig

Background:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Synonyms: ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6

Cellular Location: Cell membrane Cytoplasm Secreted

Immunogen:
A synthetic peptide of human NRAS

Gene Symbol: NRAS

Gene ID: 4893

Swiss prot: P01111

Calculated MW: 21kDa

Recommended dilution:
WB 1:3000-5000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.