NRAS polyclonal, anti-human, rat

Background:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML).

Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1

Antigen Types:
Synthetic Peptide

Gene Name:
NRAS
Gene ID:
4893
Primary Accession: P01111
Other Accession: NP_002515;4893;18176 (mouse); 24605 (rat);