NRAS polyclonal (C-term), anti-human
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In stock
SKU
AC-AP7745b
Catalog Number: AC-AP7745b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14461
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14461
Applications: WB
Datasheet
Request Information
Background:
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
This NRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-179 amino acids from the C-terminal region of human NRAS.
Antigen Region:
147-179
Antigen Type: Synthetic Peptide
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
NCBI Accession: NP_002515.1
Other Accession: Q2MJK3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
This NRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-179 amino acids from the C-terminal region of human NRAS.
Antigen Region:
147-179
Antigen Type: Synthetic Peptide
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
NCBI Accession: NP_002515.1
Other Accession: Q2MJK3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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