NRAS polyclonal (N-term), anti-human, mouse, rat
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In stock
SKU
AC-AP7745A
Catalog Number: AC-AP7745A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14459
Applications: WB, IF, FC
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14459
Applications: WB, IF, FC
Datasheet
Request Information
Background:
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
This NRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human NRAS.
Antigen Region:
72-101
Antigen Type: Synthetic Peptide
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
NCBI Accession: NP_002515.1
Other Accession: Q04970; Q2MJK3; P08556; Q5F352
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
Other Names:
GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1
Target/Specificity:
This NRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human NRAS.
Antigen Region:
72-101
Antigen Type: Synthetic Peptide
Gene Name: NRAS
Gene ID: 4893
Primary Accession: P01111
NCBI Accession: NP_002515.1
Other Accession: Q04970; Q2MJK3; P08556; Q5F352
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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