Nrf2 polyclonal, anti-human, mouse, rat

Background:
The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK. It regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (Mares). A family of NF-E2- related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1.

Alternative Name:
NF-E2-related factor 2, NFE2-related factor 2, , erythroid derived 2, HEBP1, like 2, NF E2 related factor 2, NF-E2-related factor 2, NF2L2, NFE2 related factor 2, NFE2-related factor 2, Nfe2l2, Nrf 2, NRF2, Nuclear factor (erythroid derived 2) like 2, Nuclear factor, nuclear factor erythroid 2 like 2, Nuclear factor erythroid 2 related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2,

Application Dilution:
WB:1:500
ICC:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Nrf2 polyclonal antibody detects endogenous levels of Nrf2 protein.

Immunogen:
Peptide

MW: 68 kDa

Swiss-Prot: Q16236(Human) Q60795(Mouse) O54968(Rat)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.