Nrf2 Polyclonal Antibody

Background:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Research Area: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
erythroid derived 2, HEBP1, like 2, NF E2 related factor 2, NF-E2-related factor 2, NF2L2, NFE2 related factor 2, NFE2-related factor 2, Nfe2l2, Nrf 2, NRF2, Nuclear factor (erythroid derived 2) like 2, Nuclear factor, nuclear factor erythroid 2 like 2, Nuclear factor erythroid 2 related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2

Immunogen: Synthesized peptide derived from the C-terminal region of human Nrf2

Swissprot: Q16236

Calculated MW: 75-100 kDa
Observed MW: 75-100 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31720442/
https://pubmed.ncbi.nlm.nih.gov/31509980/
https://pubmed.ncbi.nlm.nih.gov/32399817/
https://pubmed.ncbi.nlm.nih.gov/32179202/
https://pubmed.ncbi.nlm.nih.gov/32348741/