NRG1-beta human active recombinant protein
€295.00
In stock
SKU
600341
Protein Family: Cytokines,Glycan Binding Proteins
Pathway and Disease: Cell Growth and Death, Development and Behavior, Signal Transduction, Nervous and Sensory Systems, Signaling Molecules and Interaction
Alternate Names: NGR beta 1, heregulin, HRG1 beta, neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor, Sensory and motor neuron-derived factor, GGF, HGL, HRGA, NDF, SMDFDescription:
Neuregulin 1-beta (NRG1) is one of many isoforms of NRG that contains a soluble EGF-like domain. Alpha and beta varients are distinguished by difference in length at the C terminus. The EGF-like domain signals through receptors ErbB2, ErbB3, and ErbB4 to act as a growth factor. NRG isoforms are particularly important for nervous system and cardiovasucular development. Human NRG1-beta is produced in E. coli. Recombinant human NRG1-beta is a non-glycosylated protein, containing 66 amino acids, with a molecular weight of 7.6 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug.
Applications: E, WB
Application Notes:
The activity can be determined by the ability to stimulate proliferation of MC-7 cells under serum free conditions and is typically less than 0.3 ng/mL. There is no biological assay data available at this time. Specific activity: 3.3 x 10e6 units/mg
Accession No.: Q02297-6
MW: 7600 Da
Sequence:
MSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAE
Purity:
Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 50 ug of lyophilized protein. Reconstitute with 0.5 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathway and Disease: Cell Growth and Death, Development and Behavior, Signal Transduction, Nervous and Sensory Systems, Signaling Molecules and Interaction
Alternate Names: NGR beta 1, heregulin, HRG1 beta, neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor, Sensory and motor neuron-derived factor, GGF, HGL, HRGA, NDF, SMDFDescription:
Neuregulin 1-beta (NRG1) is one of many isoforms of NRG that contains a soluble EGF-like domain. Alpha and beta varients are distinguished by difference in length at the C terminus. The EGF-like domain signals through receptors ErbB2, ErbB3, and ErbB4 to act as a growth factor. NRG isoforms are particularly important for nervous system and cardiovasucular development. Human NRG1-beta is produced in E. coli. Recombinant human NRG1-beta is a non-glycosylated protein, containing 66 amino acids, with a molecular weight of 7.6 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug.
Applications: E, WB
Application Notes:
The activity can be determined by the ability to stimulate proliferation of MC-7 cells under serum free conditions and is typically less than 0.3 ng/mL. There is no biological assay data available at this time. Specific activity: 3.3 x 10e6 units/mg
Accession No.: Q02297-6
MW: 7600 Da
Sequence:
MSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAE
Purity:
Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 50 ug of lyophilized protein. Reconstitute with 0.5 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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