NRG2 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP6223b
Background:
Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
Other Names:
Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6223b was selected from the Center region of human NRG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NRG2
Gene ID: 9542
Primary Accession: O14511
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
Other Names:
Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6223b was selected from the Center region of human NRG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NRG2
Gene ID: 9542
Primary Accession: O14511
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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