NRP1 Polyclonal Antibody

Background:
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Research Area: Cancer, Cardiovascular, Immunology, Neuroscience

Synonyms:
BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin-1, NRP1

Immunogen: Recombinant fusion protein of human NRP1 (NP_001019800.1).

Swissprot: O14786
Gene ID: 8829

Calculated MW: 68 kDa/71 kDa/103 kDa
Observed MW: 103 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.