NSD1 antibody (clone 4F1), anti-human
€435.00
In stock
SKU
AC-AT3117a
Catalog Number: AC-AT3117a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT3117a">Request Information
Background:
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
Other Names:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, Lysine N-methyltransferase 3B, Nuclear receptor-binding SET domain-containing protein 1, NR-binding SET domain-containing protein, NSD1, ARA267, KMT3B
Antigen Type:
Recombinant Protein
Gene Name: NSD1
Gene ID: 64324
NCBI Accession: NP_071900.2;NP_758859.1
Primary Accession: Q96L73
Other Accession: NM_022455
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
Other Names:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, Lysine N-methyltransferase 3B, Nuclear receptor-binding SET domain-containing protein 1, NR-binding SET domain-containing protein, NSD1, ARA267, KMT3B
Antigen Type:
Recombinant Protein
Gene Name: NSD1
Gene ID: 64324
NCBI Accession: NP_071900.2;NP_758859.1
Primary Accession: Q96L73
Other Accession: NM_022455
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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