NSE2 Polyclonal Antibody

Background:
function:E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,similarity:Belongs to the NSE2 family.,similarity:Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2/MMS21 and probably NSMCE1.,

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 27

GeneID: NSMCE2 C8orf36 MMS21

Storage: -20°C/1 year

NOTE: For Research Use Only