NT5E (clone 1D7), anti-human
€493.00
In stock
SKU
252906
Protein Family: Cellular Antigens, Enzymes
Pathway and Disease: Metabolic Disorders, Nucleotide Metabolism
Description:
NT5E (CD73 (Cluster of Differentiation 73)) is an ecto-5'-nucleotidase. NT5E catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
Alternate Names: eN, NT5, CD73, 5'-nucleotidase, ecto (CD73)
Application Notes: E: 1:10000-1:20000; IHC: 1:200-1:1000
Accession No.: Q96B60
Antigen: Purified recombinant fragment of NT5E expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Metabolic Disorders, Nucleotide Metabolism
Description:
NT5E (CD73 (Cluster of Differentiation 73)) is an ecto-5'-nucleotidase. NT5E catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
Alternate Names: eN, NT5, CD73, 5'-nucleotidase, ecto (CD73)
Application Notes: E: 1:10000-1:20000; IHC: 1:200-1:1000
Accession No.: Q96B60
Antigen: Purified recombinant fragment of NT5E expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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