NTAN1 Polyclonal Antibody

Background:
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Research Area: Cell Biology

Synonyms:
N terminal Asn amidase, N terminal asparagine amidase , N terminal asparagine amidohydrolase, NTN-amidase, PNAA , PNAD , Protein N-terminal Asn amidase, Protein N-terminal asparagine amidase, Protein N-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine deamidase, Protein NTN-amidase

Immunogen: Fusion protein of human NTAN1

Swissprot: Q96AB6
Gene Accession: BC017336

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.32 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.