NTRK1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Synonyms: MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human NTRK1

Gene Symbol: NTRK1

Gene ID: 4914

Swiss prot: P04629

Calculated MW: 87/84/77kDa

Recommended dilution:
IHC 1:100-300

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.