NTRK2 Polyclonal Antibody

Background:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Metabolism, Neuroscience

Synonyms:
AI848316, BDNF tropomyosine receptor kinase B, BDNF/NT 3 growth factors receptor, BDNF/NT-3 growth factors receptor, Brain derived neurotrophic factor receptor, C030027L06Rik, EC 2.7.10.1, GP145 TrkB, GP145-TrkB, GP145-TrkB/GP95-TrkB, GP95 TrkB, Neurotrophic receptor tyrosine kinase 2, Neurotrophic tyrosine kinase receptor type 2, Neurotrophin receptor tyrosine kinase type 2, NTRK 2, Ntrk2, NTRK2, Obesity, hyperphagia, and developmental delay, included, RATTRKB1, Tkrb, Trk B, Trk-B, TRKB, TrkB tyrosine kinase, TRKB1, Tropomyosin related kinase B, tyrosine kinase receptor B, Tyrosine receptor kinase B

Immunogen: Recombinant protein corresponding to Mouse TRKB

Swissprot: Q16620,P15209,Q63604

Calculated MW: 92 kDa
Observed MW: 90/140 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.