Nuclear Mitotic Apparatus Protein (NuMA) (clone A73-B/D12 ), anti-human
€0.00
In stock
SKU
AC-AH12019
Catalog Number: AC-AH12019
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: A73-B/D12
Applications: IHC, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: A73-B/D12
Applications: IHC, IF, FC
Datasheet
Request Information
Background:
Recognizes a phosphorylated protein of 228kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
Other Names:
Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}, NuMA protein, Nuclear matrix protein-22, NMP-22, SP-H antigen, NUMA1 (HGNC:8059)
Gene Name: NUMA1 (HGNC:8059)
Gene ID: 4926
Primary Accession: Q14980
Other Accession: 4926, 325978
Recognizes a phosphorylated protein of 228kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
Other Names:
Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}, NuMA protein, Nuclear matrix protein-22, NMP-22, SP-H antigen, NUMA1 (HGNC:8059)
Gene Name: NUMA1 (HGNC:8059)
Gene ID: 4926
Primary Accession: Q14980
Other Accession: 4926, 325978
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