Nucleophosmin (clone 7H10B9), anti-human, monkey
€421.00
In stock
SKU
252594
Catalog Nr.: 252594
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC, IF
Datasheet
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Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC, IF
Datasheet
Request Information
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Cell Growth and Death
Description:
Nucleophosmin (NPM) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Alternate Names: Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Numatrin, Nucleolar protein NO38, NPM1, NPM
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: P06748
Antigen: Purified recombinant fragment of human NPM expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
Nucleophosmin (NPM) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Alternate Names: Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Numatrin, Nucleolar protein NO38, NPM1, NPM
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: P06748
Antigen: Purified recombinant fragment of human NPM expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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