Nucleophosmin polyclonal, anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Cancers, Cell Growth and Death

Description:
Nucleophosmin is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. Nucleophosmin binds ribosomes presumably to drive ribosome nuclear export. Nucleophosmin associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. Nucleophosmin acts as a chaperonin for the core histones H3, H2B and H4. A chromosomal aberration in nucleophosmin is found in a form of non-Hodgkin lymphoma.

Alternate Names: Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Numatrin, Nucleolar protein NO38, NPM1, NPM

Application Notes: E: 1:10,000-1:50,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P06748

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human nucleophosmin.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.