Nucleophosmin polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
NPM1(Nucleophosmin/Nucleoplasmin family, member1), also known as NPM, nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. The NPM1 gene maps to chromosome 5q35. Chan et al. (1989) found that nucleophosmin is a nucleolar phosphoprotein that is more abundant in tumor cells than in normal resting cells. Stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes, was accompanied by an increase in nucleophosmin protein level. They stated that nucleophosmin is likely involved in the assembly of ribosomal proteins into ribosomes. Electron microscopic study indicated that nucleophosmin is concentrated in the granular region of the nucleolus, where ribosome assembly occurs.

Description:
Rabbit IgG polyclonal antibody for Nucleophosmin (NPM1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
B23 antibody, MGC104254 antibody, NMP1 antibody, NO38 antibody, NPM 1 antibody, NPM antibody, NPM_HUMAN antibody, NPM1 antibody, Nucleolar Phosphoprotein B23 antibody, Nucleolar protein NO38 antibody, Nucleophosmin (nucleolar phosphoprotein B23 numatrin) antibody, Nucleophosmin antibody, nucleophosmin nucleoplasmin family member 1 antibody, Nucleophosmin/B23.2 antibody, Nucleophosmin/nucleoplasmin family member 1 antibody, Nucleoplasmin Family Member 1 antibody, Numatrin antibody, OTTHUMP00000161024 antibody, OTTHUMP00000161025 antibody, OTTHUMP00000223397 antibody, OTTHUMP00000223398 antibody, TRK fused gene antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Nucleophosmin recombinant protein (Position: M1-L294). Human Nucleophosmin shares 95% amino acid (aa) sequence identity with both mouse and rat Nucleophosmin.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.