NUDT1 antibody (clone 5F11), anti-human
€435.00
In stock
SKU
AC-AT3126a
Catalog Number: AC-AT3126a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT3126a">Request Information
Background:
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Other Names:
8-dihydro-8-oxoguanine triphosphatase, 2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, NUDT1, MTH1
Antigen Type:
Recombinant Protein
Gene Name: NUDT1
Gene ID: 4521
NCBI Accession: NP_002443.3;NP_945186.1;NP_945187.1;NP_945188.1;NP_945190.1;NP_945191.1;NP_945192.1
Primary Accession: P36639
Other Accession: BC014618
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Other Names:
8-dihydro-8-oxoguanine triphosphatase, 2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, NUDT1, MTH1
Antigen Type:
Recombinant Protein
Gene Name: NUDT1
Gene ID: 4521
NCBI Accession: NP_002443.3;NP_945186.1;NP_945187.1;NP_945188.1;NP_945190.1;NP_945191.1;NP_945192.1
Primary Accession: P36639
Other Accession: BC014618
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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