NUDT15 polyclonal, anti-human
€388.00
In stock
SKU
BS71189
Background:
NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15), also known as MTH2, is a 164 amino acid protein that belongs to the nudix hydrolase family and uses magnesium as a cofactor to catalyze the conversion of 8-oxo-dGTP to 8-oxo-dGMP and diphosphate. Via its catalytic activity, NUDT15 mediates the hydrolysis of select nucleoside diphosphate derivatives and may play a role in the prevention of DNA transversions. The gene encoding NUDT15 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
Alternative Name:
MTH2, Probable 8-oxo-dGTP diphosphatase NUDT15
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NUDT15 polyclonal antibody detects endogenous levels of NUDT15 protein.
Immunogen:
Recombinant protein of human NUDT15.
MW: ~ 19 kDa
Swis Prot.: Q9NV35
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15), also known as MTH2, is a 164 amino acid protein that belongs to the nudix hydrolase family and uses magnesium as a cofactor to catalyze the conversion of 8-oxo-dGTP to 8-oxo-dGMP and diphosphate. Via its catalytic activity, NUDT15 mediates the hydrolysis of select nucleoside diphosphate derivatives and may play a role in the prevention of DNA transversions. The gene encoding NUDT15 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
Alternative Name:
MTH2, Probable 8-oxo-dGTP diphosphatase NUDT15
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NUDT15 polyclonal antibody detects endogenous levels of NUDT15 protein.
Immunogen:
Recombinant protein of human NUDT15.
MW: ~ 19 kDa
Swis Prot.: Q9NV35
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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