NUDT15 polyclonal, anti-human

Background:
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

Synonyms: MTH2, NUDT15D

Cellular Location: Cytosol

Immunogen:
Recombinant protein of human NUDT15

Gene Symbol: NUDT15

Gene ID: 55270

Swiss prot: Q9NV35

Calculated MW: 19kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.